Anti-inflammatory effect of longan seed extract in carrageenan stimulated Sprague-Dawley rats

Authors

  • Chien-Wei Hou Department of Biotechnology and Pharmaceutical Technology, Yuanpei University, Hsinchu City, Taiwan
  • Ching-Hsiao Lee Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan
  • Kee-Ching Jeng Department of Medical Research, Tungs’ Taichung MetroHarbor Hospital, Taichung, Taiwan
  • Kuo-Shu Chen Division of Allergy, Immunology and Rheumatology, Tungs’ Taichung MetroHarbor Hospital, Taichung, Taiwan
  • Yuh-Shuen Chen Department of Food Nutrition, Hungkuang University, Taichung, Taiwan
Abstract:

Objective(s): Longan seeds have been used as a folk medicine in China. Longan seed extract (LSE) is known for antioxidative, antiproliferative, hypoglycemic, and hypouremic effects. However, its anti-inflammatory effect has not been shown. Materials and Methods: In this study, Sprague-Dawley (SD) rats were given LSE orally (vehicle, 10, and 30 mg/kg) for 3 days to its test anti-inflammatory effect by injecting λ-carrageenan (CARR) in the right hind paw or lipopolysaccharide (LPS), IP. For the positive control, animals were given aspirin (20 mg/kg) orally and treated likewise. Serum or tissue samples from treated rats were collected after 3 hr of stimulation. Regarding the in vitro study, BV2 microglial cells were stimulated with LPS in the presence of LSE or normal saline for 10 min or 24 hr for Western blot and ELISA assay, respectively. Results: LSE reduced CARR-induced edema in the experimental animals. LSE also reduced LPS/CARR-induced nitric oxide (NO), interleukin-1β (IL1β), IL6, and COX2 productions. These inflammatory factors were also reduced dose dependently by LSE in LPS-stimulated BV2 cells. Furthermore, Western blot analysis revealed that LSE inhibited LPS activated c-Jun NH2-terminal protein kinase (JNK), extracellular signal-regulated kinases (ERKs), and p38 MAP kinases signaling pathways, caspase-3, inducible NO synthase, and COX2 expressions. Conclusion: LSE pretreatment suppressed CARR- and LPS-induced inflammations and these effects might be through the inhibition of MAP kinases signaling pathways and inflammatory factors.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Anti-inflammatory effect of Allium akaka extract on the inflammation induced by carrageenan in rats

Background and objectives: Allium akaka, locally known “Valak” a member of the Amaryllidaceae family, is widely used in Iranian folk medicine for its wound healing, antibacterial, anthelmintic, and diuretic properties. The aim of the present work was to evaluate the anti-inflammatory effect of Allium akaka hydro-alcoholic extract on carrageenan-induce...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Anti-inflammatory effect of licorice (Licorice common) root extract on acute carrageenan-induced inflammation in rat

There are some evidences regarding anti-allergic and anti-inflammatory effects of Licorice common in traditional medicine and its usefulness in Diabetes mellitus and Diabetes insipidus and its stimulatory effect on admeocortical gland. This medicinal plant contains glycyrrhizin, sterogenic substances, cumarins, flavonoids, sterols, choline, asparagine and glaberin. Glycyrrhizin and glaberin hav...

full text

Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley rats.

The anti-inflammatory properties of Loasa speciosa and Loasa triphylla (Loasaceae), Urtica leptuphylla and Urera baccifera (Urticaceae), and Chaptalia nutans (Asteracene) were studied using the carregeenan induced rat paw edema model. Aqueous extracts of each plant were made according to the ethnobotanical use. The hippocratic assay was made with female rats; the dose used was 500 mg/kg i.p. an...

full text

Partial Inhibitory Effect of Ethanol Extract of Lepidagathis alopecuroides (Vahl) on Spermatogenesis in Sprague-Dawley Rats

The aim of this investigation was to evaluate the inhibitory effect of ethanol extract of Lepidagathis alopecuroides on spermatogenesis in mammalian system. Thirty-six adult male Sprague-Dawley rats were used for this investigation and were divided into six groups of six rats each (A-F). Groups B-F were administered ethanol extracts of L. alopecuroides orally at a daily dose of 50-250 mg/kg bod...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 19  issue 8

pages  870- 874

publication date 2016-08-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023